Inheritance filters

Modes and options

You can filter for the following inheritance patterns:

• Autosomal Recessive - Homozygotes: Autosomal variants that are homozygous (Hom) in the proband and other affected family members (if any), and heterozygous (Het), reference (Ref), or have no coverage (No Cov) in the unaffected members.

• Autosomal Recessive - Compound Heterozygotes: Two or more autosomal het variants in the same gene inherited from different parents. This filter excludes haplotype variant types.

• X-Linked Recessive: X-chromosome variants in a male proband where zygosity is Het, Hom, or Hemi in the proband, Het, Ref, or No Cov in the unaffected mother, and Ref or No Cov in the unaffected father.

• X-Linked Dominant: X-chromosome variants where zygosity is Het, Hom, or Hemi in the proband, Het in the affected mother, and Ref or No Cov in the unaffected father.

• De Novo Dominant: Variants where zygosity is Het in the proband and Ref in both unaffected parents.

• Autosomal Dominant: Autosomal variants where zygosity is Het in the proband and affected family members and Ref in unaffected family members.

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