# V35 Patches

<table><thead><tr><th width="155">Patches</th><th>Date</th></tr></thead><tbody><tr><td>V35.9</td><td>November 3, 2025</td></tr><tr><td>V35.8</td><td>May 25, 2025</td></tr><tr><td>V35.7</td><td>April 9, 2025</td></tr><tr><td>V35.6</td><td>March 4, 2025</td></tr><tr><td>V35.5</td><td>February 4, 2025</td></tr><tr><td>V35.4</td><td>December 3, 2024</td></tr><tr><td>V35.3</td><td>September 4, 2024</td></tr><tr><td>V35.2</td><td>July 24, 2024</td></tr><tr><td>V35.1</td><td>June 25, 2024</td></tr></tbody></table>

### V35.9 Update (November 3rd, 2025) <a href="#v34.4" id="v34.4"></a>

* General security updates

### V35.8 Update (May 25th, 2025) <a href="#v34.4" id="v34.4"></a>

* Analysis Tools | Preset & custom filters will now support all special characters accepted in gene lists.
* Variant Page | Updated Decipher link outs to new link structure.
* Organization Settings | Customer curated VCFs for case annotation now support PMIDs and can extract a list of articles based on a PMID. Articles are displayed on the Variant Page, in the clinical significance section, in the database badge.

### V35.7 Update (April 9th, 2025) <a href="#v34.4" id="v34.4"></a>

* Export/Report | Adding the ‘source\_gene\_map’ field to the JSON report/export.

### V35.6 Update (March 4th, 2025) <a href="#v34.4" id="v34.4"></a>

* Variant Page | Fixed an issue for some CNVs that resulted in an inactive Export to Curate button.

### V35.5 Update (February 4th, 2025) <a href="#v34.4" id="v34.4"></a>

* Pipeline | Fixed Curate annotation issue for CNV to support multiple variant annotations.
* Pipeline | Fixed issue where ploidy estimation failures caused case failure instead of triggering a lab tab alert.
* Pipeline | Fixed issue where lab tab quality check was incorrect when a case was reanalyzed with a new gene list.
* Analysis Tools | Improving re-analysis notification for ROI changes.

### V35.4 Update (December 3rd, 2024) <a href="#v34.4" id="v34.4"></a>

* Login | Fixed an issue affecting SSO integrations in legacy Emedgene clouds.
* Add new case | Fixed an issue uploading BSSH files from the UI.
* Add new case | Reanalysis | Fixed an issue reporting on tagged variants that are not present in a case reanalysis due to changed input files.
* Pipeline | Fixed issue resulting in failed ingestion of DRAGEN targeted.json where genotype is null.
* Pipeline | Added support for ingestion of software only DRAGEN outputs.
* Pipeline | Improving support of joint called files for Hom reference genotype in parents.
* Pipeline | Fixed issue causing GATK cases to fail when they contain infinity value.
* Analysis Tools | Preset Filters | Added support for the candidate gene query even when gene list is boosted.

### V35.3 Update (September 4th, 2024) <a href="#v34.4" id="v34.4"></a>

* Add New Case | Fixed an issue that caused Pending Sequencing workflows to fail in V35.
* Edit Case | Fixed a bug that prevented saving and running edited cases that were opened on versions \<V35.
* Pipeline | Fixed an issue causing more frequent case failures in V35 due to incorrect infrastructure assignment to cases where BED selection for region of interest is larger than expected.
* Analysis Tools and Report/Export | V35.0 added support for large CNVs (over 20M bp). This caused ‘case incompatible’ errors for some CNV filters and in exporting/reporting. This hotfix fixes both issues.
* Curate | Batch upload – Fixed a bug that resulted in variants added to Curate via the batch uploader to only be available in the original reference, instead of in both with liftover-on-the-fly.
* User Access | Fixed a bug causing users belonging to several domains to lose their roles when switching between domains.
* Propagations of fixes from v34.6 and v34.7 including the ability to update an organization to gnomAD 4.1 non-UKB data for SNVs/indels.

### V35.2 Update (July 24th, 2024) <a href="#v34.4" id="v34.4"></a>

* Edit Case | Fixed a bug preventing a rerun of cases when original files are no longer available on BSSH.
* Pipeline | Expanded RNA disease associated gene list in transcript selection logic. The genes added to the exception list are:
  * RNU7-1 RNA, small nuclear Aicardi-Goutieres syndrome 9
  * RNU4-2 RNA, U4 small nuclear 2
* Pipeline: Multiple fixes to improve pipeline robustness and reduce failure rates.
* Lab Tab | Fixed a bug resulting in no data loaded to the lab tab for new organizations.
* Analysis Tools | Filters | Fixed a bug for Variant Effect Filters, when moving from simple to advanced, not all variant effects were available for filtering, which also caused a variant count discrepancy.
* Analysis Tools | Preset Filters | Fixed a bug that always showed the description of removing polymorphic variants as ‘Display polymorphism: True’ although the behavior of the filter correctly removed the variants.
* Variant Page | Embedded IGV | Improved IGV performance by reducing API calls when moving between variants.
* Variant Page | Embedded IGV | Option to toggle embedded IGV off to improve performance for customers using external visualization tools.
* Export | Fixed a bug failing the export of parental data for some customers.

### V35.1 Update (June 25th, 2024) <a href="#v34.4" id="v34.4"></a>

* Edit Case | Fixed an issue that could prevent reanalysis of cases that were created via API and were missing fields required in v35.
* Cases Page | Fixed a rarely occurring issue where cases can be displayed with the good quality green icon even though they contain an insufficient coverage warning.
* Analysis Tools | Filters | Fix an issue that caused frameshift indels to disappear from variant table when moving between simple and advanced mode in the quality filters.
* Curate | Batch upload enhancement that will ensure all characters uploaded to Curate are supported in Analyze.
* Curate | Curate now supports MNVs that are supported in Analyze, which are MNV indels only.
* Curate | Fixed an issue that prevented genes with no gene metrics to be uploaded to Curate.
* Propagations from V34.5.

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