AI ACMG module (100.39.0+)

Users with a 'Manage AI ACMG' role have the ability to exclude PP5 and BP6 tags from ACMG classification. These tags rely on external assertions without independent evidence and may introduce bias (Biesecker et al. 2018).

This option is enabled by default.

  • When enabled: PP5 and BP6 tags will not be used in ACMG classification. If either tag is positive (by AI or manual input), a warning message will be displayed in the ACMG section of the variant page.

  • When disabled: The tags will be included, and no warning sign will be shown.

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