Variant page top bar

The Variant page top bar displays:

1. Case ID,

2. Gene symbol,

3. Variant Type,

4. Genomic location of the variant,

5. Variant Interpretation notes if available,

6. Variant tag field.

   If the variant has been tagged manually (besides or instead of automatic tagging by the AI Shortlist), the user-selected tag will be shown. Otherwise, you'll see an automatically selected tag or N/A for no tag. Clicking on the Variant tag field lets you review a record of tagging in a dropdown, in the Assigned tags section. The variant tag menu also includes Viewed by section. Note: After a case reanalysis, all variants appear as not viewed.

1. A link to your Curate database.

V37 and below: If the variant is already in your Curate database, you will see an Open Curate button. Otherwise, you will see an Export to Curate button.

V38+: Clicking on this button will open a menu with 3 options:

1. If the variant is not already in your Curate database, you will see an Add to Curate button. Clicking this button adds the variant to Curate for further review and editing.

2. If the variant is already in your Curate database, and you have the “kms_export” role, you will see an Update in Curate button. Clicking this button updates the variant record in Curate with information from the current Analyze session, including:

   1. Pathogenicity

   2. Variant interpretation

   3. Gene-related disease (unless it is custom)

   4. Selected transcript (unless it is custom)

   5. ACMG data (classification, score, tags, tag strength, tag notes)

3. If the variant is already in your Curate database you will also see an Open in Curate button.