V37 Patches

Patches	Date
V37.4	June 25, 2025
V37.3	May 25, 2025
V37.2	April 6, 2025
V37.1	March 5, 2025

V37.4 Update (June 25th, 2025)

• Add New Case | New capability to blacklist genes from inclusion in the AI shortlist for further noise reduction or other needs. This is currently only available through a support request.

• Lab Quality | Fixed an issue preventing DRAGEN reports from generating for customer starting from VCF and pushing metrics files.

• Genome View | Fixed an issue that prevented users from viewing the TNS track for chromosome 1.

• Genome View | Fixed an issue preventing the karyogram from loading for WES/panel cases.

• Analysis Tools | Fixed an issue preventing ‘Known Variants’ filter from being saved into a Preset Filter.

• Variant Page | Visualization | Fixed an issue where some population tracks were generically labeled. The following tracks are now correctly labeled: DGV Gold, Decipher Healthy Pop.

• Propagations from 36.7.

V37.3 Update (May 25th, 2025)

• Pipeline | DRAGEN 4.3 Targeted | Fixed a rarely occurring issue where SMN variants are duplicated.

• Genome View | Changed the default scale for the LogR/TNS track from -2 to 2 (instead of -3 to 3) based on customer usability feedback.

• Variant Page | Variant interpretation box | Fixed an issue causing long load time to make the interpretation available for editing.

• Variant Page | Summary | Fixed an issue where ACMG classification changes were not updated to summary tab.

• Variant Page | Evidence | Fixed an issue where ACMG reclassify button was active even when the variant is not eligible for reclassification.

• Settings | Presets | Fixed an issue in preset v1 to v2 migration that converted some numbers to their scientific notation.

• Settings | Presets | Fixed an issue in preset v1 to v2 migration that caused filters to reorder when having a duplicated name.

• Curate | Unified variant validations to a single mechanism for consistency from Analyze and Curate. Curate now accepts variants with unknown positions (both for protein and coding), which are represented in HGVS by "?".

• Propagations from 35.7, 35.8 and 36.6.

V37.2 Update (April 6th, 2025)

• Add New Case | BSSH Integration | Will pass QcPassed, and also Undefined datasets if no QcPassed are available.

• Pipeline | Fixed an issue causing cases to be delivered with no AI results after a failure/rerun.

• AI Shortlist | Fixed an issue where AI did not prioritize variants in an organization’s curated genes if they are Genes of Unknown Significance.

• Analysis Tools | Presets | Added support for Array calling methodology in Quality Filters.

• Analysis Tools | Filters | Fixed a UI issue where for Polymorphism Advanced filters indicators were not aligned with selection.

• Variant Page | Evidence | Fixed an issue where ACMG classification evidence text was misaligned with actual calculation.

• Organization Settings | Fixed a UI issue where if a dot appears in file name, file type always shown as text.

• Report/Export | HGNC IDs are also available for CNVs.

• Propagations from 35.7 and 36.5.

V37.1 Update (March 5th, 2025)

• Pipeline | For integrated DRAGEN analyses running on ICA via the ICA runner component, improved integration stability.

• Genome View | Added a warning that in the genome view, only the largest 500 variants are displayed.

• Analysis Tools | Fixed an issue where prediction score filters were intermittently not working for panel cases in v37.0.

• Analysis Tools | Fixed an issue where search by position in preset filters for GRCh38 was not working in v37.0.

• Analysis Tools | Fixed an issue where preset filters were showing an error message even if filters are retrieved.

• Curate | Now supports the import of start loss variants (p.Met1?).

• Propagations from 35.6 and 36.4.