V36 Patches

Patches	Date
V36.2	December 11, 2024
V36.1	October 16, 2024

V36.2 Update (December 11th, 2024)

• Organization Settings | DRAGEN arguments | Automatically converting a DRAGEN 4.2 high sensitivity setting ‘vc-enable-high-sensitivity-mode=true’ to the DRAGEN 4.3 equivalent ‘vc-enable-mosaic-detection=true’ to prevent case failure and equivalent outputs.

• Add new case | BSSH integration | Fixed an issue causing intermittent errors in VCF ingestion for customers with many BSSH projects.

• Add new case | Fixed an issue preventing adding new cases with json files.

• Pipeline | Fixed an issue that could cause duplicate variant ingestion from cases with multiple DRAGEN VCFs. The pipeline preferentially annotates the first appearance of a variant according to calling methodology rank order:

  1. "TARGETED" 2. "STAR_ALLELE" 3. "STR_REPEAT_EXPANSION" 4. "MRJD" 5. "FORCED_GENOTYPING" 6. "SMALL_VARIANT" 7. "CNV_READ_DEPTH" 8. "SV_SPLIT_END" 9. "UNKNOWN"

• Pipeline | Fixed an issue that rarely caused genome cases to get stuck in ‘In Progress’ state.

• Pipeline | Fixed an issue with missing FILTER values for trio cases.

• Pipeline | Fixed issue resulting in failed ingestion of DRAGEN targeted.json with null values.

• Analysis Tools | Visualizations | Fixed an issue where VCF track was sometimes missing from visualization.

• Versions tab | Fixed an issue where input files are sometimes missing from the versions tab.

• Propagations from v35.4

V36.1 Update (October 16th, 2024)

• Fixed an issue with the DRAGEN targeted.json caller that resulted in missing variants in a case.

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